Category: Pellagra disease

Pellagra disease

Pellagra disease is due to niacin deficiency (vitamin B3, nicotinamide, niacinamide or nicotinic acid deficiency) and was affecting whole population in the early 1900s in Southern states of USA.

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Signs and symptoms of pellagra disease

Early signs and symptoms of pellagra manifest as loss of weight, weakness, fatigue, muscular and joint pains, backache, lassitude, headache, anxiety, irritability, depression, loss of appetite, indigestion, constipation, and skin lesions and rashes without any obvious causes.

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Causes of pellagra disease

Causes of pellagra disease are malnutrition or malabsorption of niacin (vitamin B3), and/or tryptophan (an essential amino acid). Depending on the formative factors pellagra may be primary or secondary.

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Diagnosis and treatment of pellagra disease

It will be easier for diagnosis and confirmation of the presence of pellagra disease, if all the three "D" symptoms (dermatitis, diarrhea and dementia) are present.
Nowadays the diagnosis can be confirmed by the measurement of excretion of N-methylnicotinamide per day in urine.

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Dr.Joseph Goldberger research contribution on pellagra disease

Dr Joseph Goldberger to prove his point and to silence his detractors, injected blood of pellagra affected into his body and also on his assistant. He also took swabs of nasal and throat secretions of the patients and rubbed onto his nose and throat.

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