Showing posts with label types. Show all posts
Showing posts with label types. Show all posts

Types of carbohydrates

   ›      ›   Types of carbohydrates.
Carbohydrates are one of the basic types of nutrients. Their primary function is to provide energy for the body.
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The term carbohydrate, literally means "hydrates of carbon" as most of the forms of carbohydrates have the empirical formula CH2O. More accurately, carbohydrates are now defined as polyhydroxy aldehydes and ketones. They are classified as simple or complex carbohydrates, depending on the type of their chemical structure.

In food science and biochemistry, the term carbohydrate is used synonymously for saccharide, a group that includes sugars, starch and cellulose. The origin of the word saccharide is from the Greek word σάκχαρον (sákkharon), meaning 'sugar.' Depending upon the chemical structure, the saccharides are divided into monosaccharides, disaccharides, oligosaccharides and polysaccharides. The term 'sugars' is used synonymously for saccharides, particularly for monosaccharides and disaccharides.

Most types of compounds with formula Cm (H2O) n are termed carbohydrates. In biochemistry, those compounds with one (formaldehyde 0r CH2O) or two (glycolaldehyde or C2H4O2) carbon atoms are excluded.
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In food science, sugars (monosaccharides and disaccharides) are considered simple carbohydrates (found in fruit juices, honey and table sugar) and starch and fiber (oligosaccharides and polysaccharides) are considered complex carbohydrates (found in cereals, bread and pasta).

Some nutritionists use the term complex carbohydrate to refer to digestible and indigestible saccharide present in unprocessed whole food, as opposed to that present in processed and refined type of food products, table sugar and refined glucose.

Simple carbohydrates

Simple carbohydrates have one or two sugar units. They occur in fruits, milk products, certain vegetables, table sugar, honey, candy, syrups, carbonated beverages, cane juice and beet. Monosaccharides and disaccharides are the two types of simple saccharides. The food having high levels of simple type of carbohydrates may be deficient in fiber, minerals and vitamins.

Monosaccharides

The common monosaccharide type of carbohydrates are glucose, fructose, and galactose. Monosaccharides have single sugar unit. Of these, glucose is the main saccharide metabolized by the body to produce energy. Other types of monosaccharides after being absorbed from the intestine, have to be converted into glucose in the liver for utilization.

Galactose is present in the nature in small quantities and it combines with glucose in the milk to create lactose, milk sugar. Fructose has the same chemical formula but a completely different type structure. Fructose is present in fruits, honey and high-fructose corn syrup.

Disaccharides

Disaccharide type of carbohydrates have two sugar units. The common examples are, sucrose, lactose and maltose. The condensation of two monosaccharides and release of one water molecule creates a disaccharide. Sucrose is the common table sugar has molecules of glucose and fructose. Sucrose is the sweetest of all the disaccharides. It is extracted from sugar cane or sugar beet.

Maltose or malt sugar contains two glucose molecules. It is an important component of barley malt used in breweries. The condensation of glucose and galactose creates lactose molecule. Lactose, or milk sugar is digested by the enzyme lactase. Some people lose this ability to digest lactose and develop lactose intolerance.

Complex carbohydrates

Complex type of carbohydrates have more than two sugar units. They occur in whole-grains, cereals and in vegetables such as beans, peas, potatoes, corn, green peas, lentils and peanuts. Oligosaccharides and polysaccharides are the two types of complex saccharides. The food having high levels of complex saccharides may also contain dietary fiber, vitamins and minerals.

Oligosaccharides

Oligosaccharide type of carbohydrates often have a chain of three to ten monosaccharide units. Several fruits and vegetables contain fructo-oligosaccharides bonded by short chains of fructose molecules. Dietary fibers are galacto-oligosaccharides present in several natural foods. Apart from functioning as prebiotics, these types of carbohydrates are helpful in stimulating the activity of beneficial bacteria in the colon and also provide bulkage for stimulating peristalsis.

Polysaccharides

In nature most of the carbohydrates exist as polysaccharides. These types of carbohydrates have long chain (more than ten) of monosaccharide units. They may have linear or highly branched structure. Starch, glycogen, cellulose and chitin are some of the types of polysaccharides. Intestinal amylases enzymes break down starch into monosaccharide units for absorption. Starch is present in potatoes, beans, cereals and grains. Glycogen is an energy reserve and is primarily made by the liver and the muscles.

Cellulose is the most abundant carbohydrate in nature and is the most abundant of all biological molecules. Cellulose is the main component of the plant cells. There are no side chains in cellulose and the linear molecules lie close together. Human beings lack enzymes to digest cellulose. Chitin and pectins are the other natural polysaccharides, being indigestible, have no direct value in human food. The bacteria present in the colon can digest these fibers and an energy value of 2kcal/g (8.4kJ) may be contributed by these carbohydrates.

Some of the dietary fibers are arabinoxylans, cellulose, inulin, lignin, waxes, chitins, pectins, beta-glucans and oligosaccharides. These carbohydrates function as prebiotics and also provide bulkage for stimulating peristalsis. They are particularly helpful in lowering the glycemic index of the ingested food. Dietary fibers slowing down the digestion and absorption of carbohydrates in the intestines.
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References:
1.http://www.diabetes.org/food-and-fitness/food/what-can-i-eat/understanding-carbohydrates/types-of-carbohydrates.html
2.Kiens B, Richter EA. Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. Am J Clin Nutr. 1996 Jan;63(1):47-53.
3.http://www.cdc.gov/nutrition/everyone/basics/carbs.html
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Current topic in nutrition, deficiency & diseases: Types of carbohydrates.

Types of kidney stones

   ›      ›   Types of kidney stones.
Kidney stone, also known as kidney calculus or renal calculus, is a solid mass made of crystal-forming substances in the urinary system. Though all types of kidney stones originate in the kidneys, they may be found in the ureters, bladder and urethra.
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Many renal calculi of small sizes are formed and passed without causing symptoms. If the calculus is 3 mm or more, it may cause blockage of the ureter and associated renal colic pain.

Types of kidney stones

There are several different types of kidney stones. Urolithiasis refers to all types of calculi originating anywhere in the urinary system. In relation to the type of their location, renal calculi are categorized as nephrolithiasis (kidney), ureterolithiasis (ureter) and cystolithiasis (bladder). Another type of classification pertains to the type of crystal forming minerals and organic compounds constituting these calculi.

Renal calculi containing calcium

Most of the kidney stones are made of calcium compounds, especially calcium oxalate. Other calcium compounds are calcium phosphate in the form of calcium hydroxyphosphate (apatite), calcium phosphate carbonate (carbonate apatite) and brushite (CaHPO4·2H2O).

The calcium oxalate uroliths exist in combined monohydrate and dihydrate forms.
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The calcium oxalate dihydrate (CaC2O4·2H2O) type of crystals are octahedral in shape. The calcium oxalate monohydrate (CaC2O4·H2O) type of crystals vary in shape, and can be shaped like dumbbells, spindles and ovals.

The calcium oxalate calculi formation is much dependent upon the type of diet taken. Low calcium diet can lead to increased oxalate absorption from the intestine and its increased excretion in the urine. The concentration of urine and availability of oxalate in the urine increase the risk of oxalate urolith formation. High intakes of dietary oxalates, high dietary sodium, low fluid intake, low potassium intake, low citrate intake and low magnesium intake are other risk factors for developing calcium oxalate kidney stones.

Calcium phosphate renal calculi have an underlying medical cause. These types of calculi are usually associated with systemic disorders like primary hyperparathyroidism, secondary hyperparathyroidism, renal tubular acidosis, hyperphosphaturia and hypercalciuria. The availability of calcium and PO43- in the urine helps in seeding of these types of uroliths. Urine dilution with sufficient intake of water and reducing sodium intake to reduce sodium and calcium excretion can help in reducing the risk factors and recurrence.

Struvite type of renal calculi are mostly composed of struvite (magnesium ammonium phosphate). Struvite calculi also contain deposits of calcium carbonate-apatite. Infection in the upper urinary tract causes these types of uroliths. Struvite kidney stones can form only when the urine is alkaline and saturated levels of magnesium ammonium phosphate are present in urine. The urease-producing types of bacteria cause conversion of urea in the urine into carbon dioxide and ammonia by the catalytic action of the enzyme urease. Ammonia increases the pH of urine and also reacts with the magnesium and phosphate ions in the urine to form these types kidney struvite.

These types of calculi are associated with an excessive amount of uric acid in the urine (hyperuricosuria) with or without an excessive amount of uric acid in the serum (hyperuricemia). The major factors for the formation of uric acid uroliths are, chronic dehydration, low urine output, concentrated urine output, rich animal protein diet, excessively acidic urine, certain metabolic abnormalities, obesity and affliction by gout. Certain hereditary factors may also play a part in the formation of these types of kidney nephrolith. Uric acid and oxalate stones are common in patients with inflammatory bowel disease (Crohn's disease or ulcerative colitis) and in patients who had undergone colon resection.

Individuals suffering from cystinuria, cystinosis and Fanconi syndrome develop these uroliths. Cystinuria is a hereditary disorder running in families. It causes the kidneys to excrete the amino acid cystine in the urine. Cystine calculus formation can be treated by alkalinizing urine and restricting dietary animal protein, especially red meat.

Struvite have the potential to grow into staghorn uroliths. Staghorn nephrolith are branched and occupy a large portion of the renal pelvis and one or more of calices. Cystine or uric acid calculi, either in pure form or mixed with other components may also grow into staghorn. These type of kidney stones, if not treated early and properly, have the great risk of causing, permanent kidney damage, renal failure and life threatening sepsis.

Persons affected by xanthinuria often produce nephrolith composed of xanthine. In very rare cases, medications like indinavir, acyclovir, sulfadiazine and triamterene may get deposited as kidney stones.
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Related topics in nutritional deficiency diseases:
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References:
1.http://kidney.niddk.nih.gov/kudiseases/pubs/stonesadults/
2.http://www.kidney.org/atoz/content/diet.cfm
3.http://kidney.niddk.nih.gov/kudiseases/pubs/kidneystonediet/index.htm
4.Kristensen C, Parks JH, Lindheimer M, Coe FL. Reduced glomerular filtration rate and hypercalciuria in primary struvite nephrolithiasis. Kidney Int 1987; 32:749.
5.Viprakasit DP, Sawyer MD, Herrell SD, Miller NL. Changing composition of staghorn calculi. J Urol 2011; 186:2285.
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Current topic in nutritional deficiency diseases: Types of kidney stones.

Types of proteins


Proteins types are categorized as per their structure, chemical composition and biological function.

Proteins types in relation to the structure

Proteins are made up of long chains of amino acids the sequence of which is decided by gene expression. A simple polypeptide chain of amino acid is called monomeric chain and those with several polypeptide chains and bonds are called oligomeric types. With relation to the structure and number of amino acids present and the nature of bonding, they are broadly categorized into four classes. Primary structure:
This is a basic structure made up of amino acids chains and the sequence is defined by the gene expression.
Secondary structure:
In these proteins covalent bonding within and outside the chains is made and a structure, usually of helix shape, is formed.
Tertiary structure:
In these types of proteins the structure is much more complex.
These structures are three dimensional in nature with complex formations of folds and loops due to repulsion of like charged molecules and attraction of oppositely charged molecules.
Quaternary structure:
These types of proteins are very large complex molecules with many many polypeptide chains. There are two main classes of quaternary structure and they are scleroproteins and globular proteins.
Scleroproteins:
These are also called fibrous proteins. They form long rod or wire-like shaped filaments. these are not soluble in aqueous solutions.
They are usually inert and are storage or structural types of protein having role in supportive and protective function.
They are found in bone matrix, connective tissues, muscle fiber and tendons. Some of the examples of this class are collagen, elastin, keratin and fibroin (in silk).
These are also called spheroproteins having globe like structure and are soluble in aqueous solutions. Many types of enzymes, catalysts, hormones, transporters, signal transduction proteins, plasma, coagulation factors, growth factors and hemoproteins come under this category. Nucleosome, spliceosome, signal recognition particle and ribonucleoprotein are complexes with many components.

Types of proteins based on chemical composition

Depending upon the chemical composition, they are classified as simple or conjugated proteins.
Simple proteins:
Simple types contain only amino acids and do not contain any other chemical or chemical groups.
Conjugated proteins:
Many of these contain apart from amino acids other metal and chemical components and are named conjugated proteins.
The non amino acid parts are called prosthetic groups.
Some of the conjugated types and their prosthetic groups are given below.
Lipoproteins:
These conjugated protein types contain lipids in their biochemical assembly.
Lipid groups may be bound non-covalently or covalently.
Many protein like structural proteins, enzymes, transporters, antigens, toxins, adhesins, HDL (high density lipoproteins), LDL (low density lipoproteins), mitochondria and pathogen lipoprotein are lipoproteins.
Glycoproteins:
These conjugated proteins contain glycans (oligosaccharide chains) covalently attached to the side-chains of polypeptides.
These types are very important in integral membrane proteins.
There are many important glycoproteins like mucins (present in mucus), antibodies (immunoglobulins), glycoprotein llb/llla ( found on blood platelets and required for their aggregation), components of zona pellucida surrounding ovum, structural protein in the connective tissue, egg white, blood plasma, hormones (Follicle-stimulating hormone, Alpha-fetoprotein and Thyroid-stimulating hormone, Luteinizing hormone and Human chorionic gonadotropin and Erythropoietin).
Phosphoproteins:
These are chemically bonded to compounds containing phosphoric acid. Calcineurins are one of the examples.
Hemoproteins:
These conjugated types contain heme prosthetic group bound non covalently or covalently to the proteins.
Heme consists of iron atom contained in the center of a large heterocyclic organic ring called a porphyrin.
Many hemoproteins like hemoglobin, myoglobin, cytoglobin, hemocyanin, neuroglobin and leghemoglobin are required for oxygen transport.
Hemeproteins like peroxidases, ligninases and cytochrome c oxidase have the function of catalysis.
Hemeproteins, cytochrome c and catalase have a role in electron transfer whereas for active membrane transport cytochromes are needed.
Flavoproteins: 
These contain nucleic acid derivative of riboflavin like flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD).
These have many functions in DNA repair, photosynthesis, apoptosis and cellular respiration.
Metalloproteins:
These types have a metal ion as cofactor.
Many hemeproteins, enzymes (metalloenzymes), signal transduction factors come under these types.
Some of the metals in metalloproteins are iron (hemoglobin), zinc (carbonic anhydrase), cobalt (Vitamin B12 or cobalamin), copper (superoxide dismutase), magnesium (chlorophyll, Hexokinase, Glucose 6-phosphatase, DNA polymerase), calcium (calmodulin), vanadium (vanabins), nickel (Hydrogenase, Urease), manganese (arginase), selenium (Glutathione peroxidase) and molybdenum (nitrate reductase).
Opsins:
Opsins are conjugated types present in photoreceptor cells of the retina.
Opsins bind covalently to vitamin A based retinaldehyde chromophore and function the vision perception.
Other conjugated proteins like cytochrome have function in electron transport and phytochromes function in plants for photoreception regulating photoperiodism, circadian rhythms and germination of seeds.

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What are Proteins made of ?
Proteins synthesis
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Daily requirements
Food sources

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Different types of proteins.